Alexey Popov,Elizabeth Enlow,James Bourassa,Colin R. Gardner,Hongming Chen,Laura M. Ensign,Samuel K. Lai,Tao Yu,Justin Hanes,Ming Yang
申请号：
US14731921
公开号：
US20150265542A1
申请日:
2015.06.05
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.
