The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host using a transcutaneous analyte sensor system including an applicator (12), a mounting unit (14), an electronics unit (16), a base (24), a sensor (32), and one or more contacts (28) configured to provide secure electrical contact between the sensor and the electronics unit (16).