COMPOSITION PHARMACEUTIQUE POUR LA PRÉVENTION OU LE TRAITEMENT DU PRURIT, CONTENANT UN DÉRIVÉ DE PYRAZOLE EN TANT QUE PRINCIPE ACTIF, ET PROCÉDÉ DE DÉPISTAGE POUR SA DÉTECTION
Seoul National University R&DB Foundation;Kanzen Co., Ltd
发明人:
OH, Uhtaek,LEE, Ji Yeong,AN, Sung Ae
申请号：
EP18764324
公开号：
EP3593799A4
申请日:
2018.03.06
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The present invention relates to a pharmaceutical composition for preventing or treating pruritus, containing a pyrazole derivative as an active ingredient, and a screening method for detecting the same. A pharmaceutical composition for preventing or treating pruritus, according to the present invention, can relieve the symptoms of pruritus by inhibiting the activity of intracellular Mrgpr X1, and can relieve the symptoms of pruritus by inhibiting the activity of intracellular hH1R, thereby being usable also as a medicine for preventing or treating histamine-mediated pruritus. In addition, it has been confirmed through dry skin mouse model experimentation that the composition also has significant alleviation effects on dry skin, thereby being usable as a medicine for treating dry skin. Furthermore, the pharmaceutical composition according to the present invention can relieve the symptoms of pruritus caused by psoriasis, thereby being usable also as a medicine for treating psoriasis. Moreover, the pharmaceutical composition according to the present invention can maintain stable activity, even during in vivo drug administration, without causing adverse reactions.
