Methods for the treatment of cancer, including glioblastoma multiforme (GBM)and recurrent glioblastoma multiforme(RGBM). The method includes administering to a patient a plurality ofextraneous antineoplastons and a plurality of targeted agents.The plurality of extraneous antineoplastons may include two or moreantineoplastons selected from phenylacetylglutaminate sodium(PG), phenylacetylisoglutaminate sodium (iso-PG), and phenylacetate (PN). Theplurality of targeted agents may include two or moreagents selected from bevacizumab, pazopanib, sorafenib, dasatinib, andeverolimus.
