Pharmaceutical composition comprising 5- (4- (aminosulfonyl) phenyl) -2,2-dimethyl-4- (3-fluorophenyl) -3 (2H) -furanone, and capsule formulation comprising the pharmaceutical composition

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专利权人:

クリスタルジェノミクス・インコーポレイテッド

发明人:

キム，ビュン‐ハ,アン，シク・イル,パク，ジェ‐ヨン,キム，テ・リョン,チョウ，ジョン・ミュン,ロ，ショング,キム,ビュン‐ハ,アン,シク・イル,パク,ジェ‐ヨン,キム,テ・リョン,チョウ,ジョン・ミュン,ロ,ショング

申请号：

JP2016549250

公开号：

JP6250911B2

申请日:

2015.01.29

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

The present invention relates to a pharmaceutical composition including (i) the compound of Formula 1 described in the specification or a pharmaceutically acceptable salt thereof, (ii) a pharmaceutically acceptable diluent, and (iii) a pharmaceutically acceptable lubricant. The compound of Formula 1 or pharmaceutically acceptable salt thereof has a 50% volume particle diameter (d(0.5)) of 3 μm to 9 μm. The pharmaceutical composition of the present invention has the advantages of good stability, high dissolution rate, improved content uniformity, and excellent pharmacokinetic properties. Due to these advantages, the pharmaceutical composition of the present invention is effective in treating inflammation or pain.

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