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Drug delivery systems comprising weakly basic drugs and organic acids
专利权人:
Inc.;Aptalis Pharmatech
发明人:
Venkatesh, Gopi M.
申请号:
AU2007211101
公开号:
AU2007211101B2
申请日:
2007.01.29
申请国别(地区):
AU
年份:
2013
代理人:
摘要:
A pharmaceutical dosage form such as a capsule, a conventional or orally disintegratingtablet capable of delivering a nitrogen (N)-containing therapeutic agent havinga pKa in the range of from about 5 to 14 into the body in a sustained- released fashion,in order to be suitable for a twice- or once-daily dosing regimen, comprises atleast one organic acid, which solubilizes the therapeutic agent the drug priorto releasing it into the hostile intestinal environment wherein said weaklybasic drug is practically insoluble. The unit dosage form is composed of a multitudeof multicoated particulates (
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