APPLICATION À DES HUMAINS DE LYMPHOCYTES T COMPRENANT UN RÉCEPTEUR ANTIGÉNIQUE CHIMÉRIQUE (CAR)

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专利权人:

THE UNIVERSITY OF TEXAS SYSTEM;BOARD OF REGENTS

发明人:

COOPER, LAURENCE, J.N.,WANG-JOHANNING, FENG,TORIKAI, HOROKI,HULS, HELEN,HURTON, LENKA,KRISHNAMURTHY, JANANI,OLIVARES, SIMON,ZHANG, LING

申请号：

EP14798046

公开号：

EP2997134A4

申请日:

2014.05.14

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/