COMEAU, MICHAEL R.,麦可Ｒ. 寇梅奥,麥可Ｒ. 寇梅奧,SMOTHERS, JAMES F.,詹姆士Ｆ. 史玛瑟斯,詹姆士Ｆ. 史瑪瑟斯,YOON, BO-RIN P.,尹宝琳,尹寶琳,MEHLIN, CHRISTOPHER,克里斯朵夫梅林,麦可R. 寇梅奥,麥可R. 寇梅奧,詹姆士F. 史玛瑟斯,詹姆士F. 史瑪瑟斯
申请号：
TW097134513
公开号：
TWI449709B
申请日:
2008.09.09
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
The present disclosure provides compositions and methods relating to antigen binding proteins which bind to human thymic stromal lymphopoietin (TSLP), including antibodies. In particular embodiments, the disclosure provides fully human, humanized and chimeric anti-TSLP antibodies and derivatives of such antibodies. The disclosure further provides nucleic acids encoding such antibodies and antibody fragments and derivatives, and methods of making and using such antibodies includi本發明之揭示提供有關結合至人類胸腺基質淋巴細胞生成素(thymic stromal lymphopoietin/TSLP)之抗原結合蛋白(包括抗體)之組成物及方法。在特別之具體例中，本發明之揭示提供完全人類、人類化及嵌合型抗-TSLP抗體及此等抗體之衍生物。該揭示進一步提供編碼此等抗體及抗體片段及衍生物之核酸，以及製造及使用此等抗體之方法，包括治療及預防與TSLP有關之發炎性及纖維化疾病之方法。
