Meningococcus adhesins NadA, App and ORF 40

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专利权人:

Novartis Vaccines and Diagnostics SRL

发明人:

Maria Arico,Maurizio Comanducci

申请号：

US14224031

公开号：

US09249197B2

申请日:

2014.03.24

申请国别(地区):

US

年份:

2016

代理人:

摘要：

NadA, App and ORF40 function as adhesins in N. meningitidis. Adhesion nad be modulated by targeting these three proteins. NadA allelic variants are also disclosed. Autoproteolytic cleavage of App is disclosed, as is removal of the activity by mutagenesis. App is processed and secreted into culture medium when expressed in E. coli. Mature App proteins are disclosed. Knockout mutants are disclosed. Vesicles from non-Neisserial hosts with heterologous adhesion expression are disclosed.

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