您的位置: 首页 > 农业专利 > 详情页

СПОСОБ IN VIVO ВИЗУАЛИЗАЦИИ РАКА
专利权人:
ДжиИ Хелткер Лимитед (GB)
发明人:
ДЖОНС Пол Александер (GB)
申请号:
RU2013111163/15
公开号:
RU2013111163A
申请日:
2011.09.29
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method for identifying and / or monitoring cancer in a subject, wherein said cancer is characterized by abnormal expression of the peripheral benzodiazepine receptor (PBR), comprising the following steps: (a) administering to said subject in vivo imaging agent of Formula I:, wherein: R is Ci ^ alkyl or Cftoralkil R is hydrogen, hydroxy, halo, cyano, Ci ^ alkyl, alkoxy, or Cftoralkil Cftoralkoksi r and independently represent Ci ^ alkyl Saralkil, or together with the nitrogen atom to which they Ac They are united to form a nitrogen-containing Salifaticheskoe ring optionally containing 1 additional heteroatom selected from nitrogen, oxygen and sulfur Ypredstavlyaet is O, S, SO, SOili CH iYpredstavlyaet CH, CH-CH, CH (CH) -SNili CH-CH-CH and wherein said in vivo imaging agent of Formula I contains an atom which is a radioisotope suitable for in vivo imaging, and (b) allowing binding of said inputted in vivo imaging agent of step (a) with a PBR, to be expressed in said subject, (c) detecting signals emitted by a radioisotope contained in said associated in vivo imaging agent of step (b) using a suitable method for in vivo imaging (g) Picture generation Nia reflecting distribution and / or amount of said signals detected in step (c) (d) determining the distribution and / or amount of expression of PBR in said subject wherein said expression is directly correlated with the distribution and / or amount of said signals represented in said image obtained in step (g) and (e) Using1. Способ идентификации и/или мониторинга ракового заболевания у субъекта, где указанное раковое заболевание характеризуется аномальной экспрессией периферических бензодиазепиновых рецепторов (PBR), включающий следующие стадии:(а) введение указанному субъекту in vivo визуализирующего агента формулы I:,где:R1 представляет собой C1-3алкил или C1-3фторалкилR2 представляет собой водород, гидрокси, галогено, циано, C1-3алкил, C1-3алкокси, C1-3фторалкил или C1-3фторалкоксиR3 и R4 независимо представля
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
相关发明人
相关专利

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充