The present invention discloses a substrate for a facial mask, the substrate is formed by Roll to Roll process and to have anti-Virus function. The mask comprises an inner layer, a middle layer and an outer layer, wherein the middle layer or the outer layer comprises a cationic metalloorganic compound for inhibiting the virus.本發明揭露一種滾軸式製程製作口罩基材,使其包含抗病毒功能。該口罩包含裏層、中層與外層,其中中層或外層包含陽離子金屬有機化合物,用於抑制病毒。