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Glycosylated GLP-1 peptide
专利权人:
Kazuyuki Ishii;Yasuhiro Kajihara;Katsunari Tezuka;Kazuhiro Fukae;Takashi Tsuji;Izumi Sakamoto;Naohiro Hayashi;Hiroaki Asai;Yuri Nambu
发明人:
Yasuhiro Kajihara,Takashi Tsuji,Izumi Sakamoto,Yuri Nambu,Naohiro Hayashi,Kazuyuki Ishii,Kazuhiro Fukae,Katsunari Tezuka,Hiroaki Asai
申请号:
US12999654
公开号:
US08765669B2
申请日:
2009.06.15
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Oligosaccharide chain added GLP-1 peptides are more stable in blood and more active in controlling blood-sugar levels than GLP-1 peptides without added oligosaccharides. Oligosaccharide chain added GLP-1 peptides having GLP-1 activity include at least one or at least two amino acids each substituted with an oligosaccharide chain added amino acid in GLP-1; a peptide having the amino acid sequence of GLP-1 with deletion, substitution or addition of one or several amino acids; or a GLP-1 analog. Oligosaccharide chain added GLP-1 peptides with at least one amino acid substituted with an oligosaccharide chain added amino acid include an oligosaccharide chain with oligo hyaluronic acid. Oligosaccharide chain added amino acids include oligosaccharide chains attached to amino acids via linkers.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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