THE PRESENT INVENTION PROVIDES A HUMAN DOSE OF AN IMMUNOGENIC COMPOSITION COMPRISING AN ANTIGEN OR ANTIGENIC PREPARATION, IN COMBINATION WITH AN ADJUVANT WHICH ADJUVANT COMPRISES AN IMMUNOLOGICALLY ACTIVE SAPONIN FRACTION DERIVED FROM THE BARK OF QUILLAJA SAPONARIA MOLINA PRESENTED IN THE FORM OF A LIPOSOME AND A LIPOPOLYSACCHARIDE WHEREIN SAID SAPONIN FRACTION AND SAID LIPOPOLYSACCHARIDE ARE BOTH PRESENT IN SAID HUMAN DOSE AT A LEVEL OF BELOW 30 µG. THE PRESENT INVENTION FURTHER PROVIDES AN ADJUVANT COMPOSITION IN A HUMAN DOSE SUITABLE VOLUME COMPRISING BETWEEN 1 AND 30 µG OF A LIPOPOLYSACCHARIDE AND BETWEEN 1 AND 30 µG OF IMMUNOLOGICALLY ACTIVE SAPONIN FRACTION PRESENTED IN THE FORM OF LIPOSOME.
