Ronald J BUCKANOVICH,George COUKOS,Andrea FACCIABENE
申请号：
US16241676
公开号：
US20190375845A1
申请日:
2019.01.07
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention provides methods of treating and enhancing efficacy of immunotherapy for a solid tumor in a subject, comprising the step of contacting the subject with a compound or composition that modulates the expression or activity of ETRB, ET-1, ICAM-1, or another protein found herein to play a role in homing of T cells to a solid tumor. The present invention also provides methods of prognosticating a solid tumor in a subject, comprising the step of measuring an expression level of a protein found herein to play a role in homing of T cells to a solid tumor, or a nucleotide molecule encoding same.
