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COMPOSITIONS AND METHODS FOR MODULATING STEM CELLS AND USES THEREOF
专利权人:
Fabien Le Grand;Michael A. Rudnicki
发明人:
Michael A. Rudnicki,Fabien Le Grand
申请号:
US13266428
公开号:
US20120213744A1
申请日:
2010.04.27
申请国别(地区):
US
年份:
2012
代理人:
摘要:
There are provided compositions and methods for modulating stem cell division decisions, in particular, division symmetry. It has been demonstrated that wnt7a acts through frizzled-7 receptor expressed on the surface of adult stem cells, e.g. satellite stem cells, to activate the planar cell polarity (PCP) pathway, thereby promoting symmetrical expansion of stem cells. The compositions and methods of the invention are useful, for example, in modulating stem cell division symmetry in vitro and in vivo, in replenishing and expanding the stem cell pool, and in promoting the formation, maintenance, repair and regeneration of tissue.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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