A pharmaceutical dosage form comprising a therapeutically effective amount of at least one opioid acetaminophen and at least a pharmaceutically acceptable excipient, in which the dosage form is retained in the stomach for at least four hour S and is suitable for the Administration of one or two times a day.It also provides a method of treating Pain by administering to a patient in need of a pharmaceutical dosage form gastrorretentiva Administration once or twice a day. Acetaminophen is found in slow release form or in the form of LIBE Immediate Release, or a combination of both.It also provides a gastrorretentiva pharmaceutical dosage form comprising a therapeutically effective amount of at least one opioid, at least one form of acetaminophen, an antagonist of Opioid and at least a pharmaceutically acceptable excipient.In which the dosage form is retained in the stomach for at least four hours and is suitable for the Administration of one or two times a day.Claim 2: pharmaceutical dosage form according to claim 1 which comprises a therapeutically effective amount of at least an opioid, acetaminophen, and at least a pharmaceutically acceptable excipient, in which the dosage form is retained in and L stomach for at least four hours, during which, on average,Between 10% and 30% per hour of Opioid initially present at time 0, was released between 0 and 2 hours under in vitro Assay with a USP Apparatus Type 1 in 50 mm phosphate, pH 6.8, and agitation between 50 and 150 rpm.Claim 3: pharmaceutical dosage form according to claim 1 or 2, comprising: a) a Core comprising at least two layers of Liberation, in which a First Layer comprising at least one opioid release, with or without acetaminophen, and a second layer of LIBE Ration comprising Acetaminophen with or without an opioid, and (b) a Coating comprising such a kernelThe dosage form is retained in the stomach for at least four hours and is suitable for the Administration of one or two times a day.Una forma de dosificac
