ТЕРНЕР Рейчел (US),ГЕРБЕР Дейвид (US),ЛОЗОЙЯ Освальдо (US),РЕЙД Лола М. (US)
申请号：
RU2012152610/14
公开号：
RU2012152610A
申请日:
2011.05.06
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A method of transplanting cells of an internal organ to a subject having an internal organ in a damaged or dysfunctional state, comprising: a. obtaining normal cells of the internal organ of the donor； b. combining cells with one or more gel-forming biomaterials to form a mixture； c. if necessary, combining the mixture with a growth medium, signaling molecules, extracellular matrix proteins, or a combination thereof； d. administering the mixture according to (b) to a subject in which the majority of the cells introduced according to (d) are located in or on at least a portion of an internal organ in vivo. 2. The method of claim 1, wherein the normal cells are stem cells, committed progenitor cells, or mature cells. The method of claim 1, wherein the internal organ is a liver, lungs, intestine, intestines, heart, kidneys, bile ducts, thyroid gland, thymus, brain, or pancreas. The method of claim 3, wherein the internal organ is a liver. The method according to claim 3, wherein the cell suspension is a suspension of liver stem cells, hepatoblasts, committed progenitor cells of the bile epithelium, or hepatocytes, or mature hepatocytes, or cholangiocytes. The method of claim 1, wherein the donor is a subject having an internal organ in a damaged or dysfunctional state, and normal cells are obtained from the intact and non-dysfunctional part of the internal organ. The method of claim 1, wherein the donor is a non-autologous donor. The method according to claim 1, wherein the donor is an embryo, newborn, child or adult. The method according to claim 1, in which1. Способ трансплантации клеток внутреннего органа субъекту, имеющему внутренний орган в поврежденном или дисфункциональном состоянии, включающий:а. получение нормальных клеток внутреннего органа донора；b. комбинирование клеток с одним или несколькими гель-образующими биоматериалами для образования смеси；с. при необходимости комбинирование смеси с питательной средой, сигнальными молекулами, белками внеклеточного
