Topical pharmaceutical composition (I) comprises mixture of excipient having microbial activity, where the composition comprises 0-1.8 mass% of preservatives comprising formaldehyde generators (imidazolidinyl urea or diazolidinyl urea), thiazine derivatives ( Kathon CG(RTM: Isothiazolinone)), chlorine derivatives (chlorhexidine), phenomic derivatives (parabens), alcohol derivatives (bronopol, phenoxyethanol, and chloroxylenol), acid derivatives (sorbic acid and benzoic acid), and/or benzalkonium chloride. ACTIVITY : Dermatological. MECHANISM OF ACTION : None given.La présente invention se rapporte à lutilisation dune combinaison dexcipients au sein dune composition pharmaceutique pour leur activité de conservateur et à la composition pharmaceutique la comprenant.