Process for the preparation of donepezil hydrochloride

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专利权人:

CIPLA LIMITED

发明人:

Rao, Dharmaraj Ramachandra,Kankan, Rajendra Narayanrao,Pathi, Srinivas Laxminarayan

申请号：

AU2009229067

公开号：

AU2009229067B2

申请日:

2009.03.24

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

The present invention provides a process for preparing donepezil or a salt thereof, the process comprising reducing a 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2- yl)methylene]pyridonium halide of formula (II), wherein X is bromide or chloride, in the presence of an ionic compound, a solvent, a catalyst and a source of hydrogen, to form donepezil and optionally converting the donepezil to the salt thereof.

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