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Pharmaceutical agent comprising a benzamide derivative as active ingredient
专利权人:
BAYER INTELLECTUAL PROPERTY GMBH
发明人:
SUZUKI, TSUNEJI,ANDO, TOMOYUKI,ISHIBASHI, MASAHIKO,SAKABE, MASAHIRO,SAKAI, IKUO
申请号:
ES00951523
公开号:
ES2536705T3
申请日:
2000.08.16
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A pharmaceutical formulation comprising a benzamide derivative represented by the formula (1): ** Formula ** in which A represents a structure shown by any one of the formula (2): ** Formula ** or a pharmaceutically acceptable salt thereof, an excipient selected from the group consisting of lactose, lactose anhydride, D-mannitol, corn starch and crystalline cellulose, a lubricant selected from the group consisting of magnesium stearate, calcium stearate, stearic acid and talc, a disintegrant selected from the group consisting of partially pregelatinized starch, calcium carmellose and sodium carboxymethyl starch, and one or more of one selected from the group consisting of an amino compound and an inorganic basic substance, wherein the amino compound is one or more of one selected from the group consisting of tris (hydroxymethyl) aminomethane, monoethanolamine, diethanolamine, triethanolamine, diisopropanolamine, triisopropanolamine, aminoacet Ato dihydroxyaluminium, arginine, creatinine, sodium glutamate, glycine, L-arginine Lglutamate and carbacol, and the inorganic basic substance is one or more of one selected from the group consisting of sodium carbonate, potassium carbonate, ammonium carbonate, sodium bicarbonate, bicarbonate potassium, sodium hydroxide, disodium phosphate and ammonia.Una formulación farmacéutica que comprende un derivado de benzamida representado por la fórmula (1):**Fórmula** en la que A representa una estructura mostrada por uno cualquiera de la fórmula (2):**Fórmula** o una sal farmacéuticamente aceptable del mismo, un excipiente seleccionado del grupo que consiste en lactosa, lactosa anhídrido, D-manitol, almidón de maíz y celulosa cristalina, un lubricante seleccionado del grupo que consiste en estearato de magnesio, estearato de calcio, ácido esteárico y talco, un disgregante seleccionado del grupo que consiste en almidón parcialmente pregelatinizado, carmelosa cálcica y carboximetilalmidón sódico, y uno o más de uno seleccionados del gr
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