Jen Cheng LIN,Chun-Chieh LIN,Hsu-Tung LEE,Yu-Ming FAN,Jui-Chi TSAI,Ying-Chi DU
申请号：
US15546949
公开号：
US20180015090A1
申请日:
2016.01.27
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to a novel type of PPARγ modulator having a pyrimido[5,4-d]pyrimidine main structure. The PPARγ modulator can enhance the expression and nuclear translocation of PPARγ in cells. The present invention also relates to a pharmaceutical composition comprising the PPARγ modulator of the invention encapsulated in a pharmaceutically acceptable cell-penetrating drug delivery system so that it can be directly delivered into cells. The present invention thus provides a method of preventing or treating PPARγ-related disorders or conditions comprising administering to a subject in need thereof a therapeutically effective amount of the PPARγ modulator of the invention or the pharmaceutical composition of the invention.
