SMALL MOLECULE INHIBITORS OF HLA-DR3 BINDING FOR TREATING AUTOIMMUNE THYROIDITIS

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专利权人:

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

发明人:

Yaron TOMER,Roman OSMAN

申请号：

US16063942

公开号：

US20200281919A1

申请日:

2016.12.20

申请国别(地区):

US

年份:

2020

代理人:

摘要：

A method for treating autoimmune thyroid disease is disclosed. The method comprises administering a molecule of molecular weight below 700 that inhibits the binding of the nonadecapeptide IPDNLFLKSDGRIKYTLNK (SEQ ID NO:1) to HLA-DRβ1-Arg74. Such compounds are found in the class of bisbenzylisoquinoline alkaloids represented by formula I

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