MAKS-PLANK-GEZELLSHAFT TSUR FERDERUNG DER VISSENSHAFTEN E.F.
发明人:
ZEEBERGER Peter KH. (DE),ЗЕЕБЕРГЕР Петер Х. (DE),STOLLFORT Per (US),СТОЛЛФОРТ Пьер (US),DE LIBERO Dzhennaro (CH),ДЕ ЛИБЕРО Дженнаро (CH),KAVALLARI Marko (CH),КАВАЛЛАРИ Марко (CH),ZEEBERGER Peter KH.,ЗЕЕБЕРГЕР Петер Х.,STOLLFORT Per,СТОЛЛФОРТ Пьер,DE LIBERO Dzhennaro,ДЕ ЛИБЕРО Дженнаро,KAVALLARI Marko,КАВАЛЛАРИ Марко
申请号：
RU2014142043
公开号：
RU0002649009C2
申请日:
2013.03.19
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
FIELD: medicine.SUBSTANCE: present invention relates to a compound useful in medicine of the general formula (XIV):(XIV) ,where A is a carbohydrate antigen of 5–900 monomers and is selected from a bacterial capsular saccharide, a viral glycoprotein saccharide, a sporozoa or parasitic saccharide antigen, a pathogenic fungal saccharide antigen or a saccharide antigen, which is specific for cancer cells, p is 1 or 2 if u is 1, p is 1, 2, 3 or 4 if u is 2, p is 1, 2, 3, 4, 5 or 6 if u is 3, p is 1, 2 , 3, 4, 5, 6, 7 or 8 if u is 4, 1 ≤ p ≤ 10, if 5 ≤ u ≤ 10, 2 ≤ p ≤ 50, if 11 ≤ u ≤ 100, 20 ≤ p ≤ 200, if 101 ≤ u ≤ 1,000, 50 ≤ p ≤ 400, if 1,001 ≤ u ≤ 10,000, u denotes the number of carbohydrate monomers of carbohydrate antigen A, L represents -L1-L2-, -L2-, -L2-L3- or -L1-L2-L3-； L1 is one of the following residues:where x is an integer from 1 to 60； Y is a bond, -NH-, -O-, -S-, -S-S-； L2 represents -CH2-, -C2H4-, -C3H6-, -C4H8-, -C5H10-, -C6H12-, -C7H14-, -C8H16-, -C9H18-, -C10H20-, -CH(CH3)-, -C[(CH3)2]-, -CH2-CH(CH3)-, -CH(CH3)-CH2-, -CH(CH3)-C2H4-, -CH2-CH(CH3)-CH2-, -C2H4-CH(CH3)-, -CH2-C[(CH3)2]-, -C[(CH3)2]-CH2-, -CH(CH3)-CH(CH3)-, -C[(C2H5)(CH3)]-, -CH(C3H7)-, -(CH2-CH2-O)n-CH2-CH2-, -CO-CH2-, -CO-C2H4-, -CO-C3H6-, -CO-C4H8-, -CO-C5H10-, -CO-C6H12-, -CO-C7H14-, -CO-C8H16-, -CO-C9H18-, -CO-C10H20-, -CO-CH(CH3)-, -CO-C[(CH3)2]-, -CO-CH2-CH(CH3)-, -CO-CH(CH3)-CH2-, -CO-CH(CH3)-C2H4-, -CO-CH2-CH(CH3)-CH2-, -CO-C2H4-CH(CH3)-, -CO-CH2-C[(CH3)2]-, -CO-C[(CH3)2]-CH2-, -CO-CH(CH3)-CH(CH3)-, -CO-C[(C2H5)(CH3)]-, -CO-CH(C3H7)-, -CO-(CH2-CH2-O)n-CH2-CH2-； n is an integer from 1 to 60； L3 represents -CO-, -O-CO-, -NH-CO-, -NH(C=NH)-, -SO2-, -O-SO2-, -NH-, -NH-CO-CH2-； R* and R# independently of each other, are a linear or branched or cyclic saturated or unsaturated hydrocarbon radical consisting of 1 to 30 carbon atoms, wherein the hydrocarbon residue may be substituted with Z1, Z2, Z3, Z4, Z5 number from 1 to 5 and substituents Z1, Z2, Z3, Z4, Z5 independently of each other a
