The invention provides compositions and methods for treating diseases associated with expression of CLL-1. The invention also relates to chimeric antigen receptor (CAR) specific to CLL-1, vectors encoding the same, and recombinant cells comprising the CLL-1 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CLL-1 binding domain.本發明提供用於治療與CLL-1表現相關之疾病的組合物及方法。本發明亦關於特異性針對CLL-1之嵌合抗原受體(CAR),編碼其之載體及包含CLL-1 CAR之重組細胞。本發明亦包括投與經遺傳修飾之細胞的方法,該細胞表現包含CLL-1結合結構域之CAR。