Disclosed are devices and methods for detecting activation of an electronic device, including a biomedical and biometric device. The electronic device can operate in a low-power mode until it is determined that the electronic device is in close proximity to or in contact with a body, and activated. The electronic device can include a first sensor including a first capacitance sensor, a second sensor, and a controller coupled to the first sensor and the second sensor. The controller can receive a first signal from the first sensor and determine that the electronic device is in close proximity to or in contact with a body based on the first signal, and receive a second signal from the second sensor and determine that the electronic device is activated based on one or both of the first signal and the second signal. The electronic device can transition from the low-power mode to an active mode in response to determining that the electronic device is activated.
