The present invention relates to compounds with an extended duration of action at the glucagon receptor as compared to native glucagon. Specifically provided are glucagon receptor agonists with modifications to the structure of native glucagon introduced to selectively agonize the glucagon receptor over an extended period of time.本發明係關於一種可比天然升糖素更能延長在升糖素受體處之作用持續時間之化合物。具體而言,提供一種升糖素受體促效劑,其已在天然升糖素結構中進行修飾,以在延長時期內選擇性促效升糖素受體。