This invention relates to tetrahydro-naphthalene derivatives and salts thereofwhich is useful as an active ingredient of pharmaceutical preparations. Thetetrahydro-naphthalene derivatives of the present invention have an excellentactivity as VR1 antagonist and useful for the prophylaxis and treatment ofdiseases associated with VR1 activity, in particular for the treatment ofurinary incontinence, urge urinary incontinence, overactive bladder, chronicpain, neuropathic pain, postoperative pain, rheumatoid arthritic pain,neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration,stroke, inflammatory disorders, asthma and COPD.
