A compound selected from the compounds of Formula I: ** Formula ** stereoisomers thereof and pharmaceutically acceptable salts thereof, wherein: Q is selected from C and N； W is selected between C and N； X is selected from CH2 and O； Y is selected from NR12, O, and S； Z is selected from O, S, NR13, CO, SO, SO2 and CR13R14； R1, R2, R3, R4, R5, and R6, which may be the same or different, are each independently selected from hydrogen, halogen, haloalkyl, alkyl, alkenyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, alkynyl, CN, -NR13R14 , -OR13, -COR13, -CO2R13, -CONR13R14, -C (>； = NR13) NR14R15, -NR13COR14, -NR13CONR14R15, -NR13CO2R14, -SO2R13, -NR13SO2NR14R15, -NR13SO2R14 and -NR13SO, alilo in, Nilo13, alilo in alkynyl, cycloalkyl, heteroaryl, aryl and heterocyclyl are optionally substituted with at least one R16 substituent, or (R1 and R2) and / or (R3 and R4) and / or (R5 and R6), together with the ring to which they are attached , form a fused ring selected from heterocyclyl and heteroaryl rings optionally substituted with at least one R16 substituent； provided that R1 is absent when Q is N, and R5 is absent when W is N； R7 is selected from hydrogen, halogen, alkyl, -O-alkyl, and -S-alkyl； R12 is selected from hydrogen and alkyl； R13, R14 and R15, which may be the same or different, are each independently selected from H, haloalkyl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl； or (R13 and R14) and / or (R14 and R15) together with the atom (s) to which they are attached, each form a ring selected from heterocyclyl and heteroaryl rings optionally substituted with at least one R16 substituent； R16 is selected from halogen, haloalkyl, alkyl, alkenyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, alkynyl, oxo, -CN, -OR ', -NR'R ", -COR', -CO2R ', -CONR'R" , -C (>； = NR ') NR "R'", -NR'COR ", -NR'CONR'R", -NR'CO2R ", -SO2R ', -SO2aryl, -NR'SO2NR" R "' , NR'SO2R "and -NR'SO2aryl, wherein R ', R" and R' "are independently selected from H, haloa
