The invention provides alkyne substituted quinazoline compounds, such as compounds of the formula (I), which are irreversible ErbB kinase inhibitors. The compounds are useful in the treatment of diseases and disorders where ErbB kinase activity is implicated such as a hyperproliferative disorder (e.g., cancer).本發明提供經炔基取代之喹唑啉化合物,諸如式(I)化合物,其為不可逆ErbB激酶抑制劑。該等化合物適用於治療涉及ErbB激酶活性之疾病及病症,諸如過度增殖病症(例如癌症)。
