A ready-to-use skin patch (1) is disclosed. The patch has a support (2) with electrostatic properties. A periphery of the support is coated with an adhesive material (3), and all or part of the non-adhesive surface of the support is covered with at least one biologically active substance (5). The biologically active substance is in the form of particles that adhere to the non-adhesive part of the support by electrostatic forces created at manufacture. A method of manufacturing the patch including how to create the electrostatic properties of the support is also disclosed.