Caroline Françoise POLLEFLIET,Hugo A.L. CORSTJENS,Lieve DECLERCQ,Daniel B. YAROSH
申请号：
US14865432
公开号：
US20160089319A1
申请日:
2015.09.25
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A method is provided for identifying a material having an efficacy for reducing color contrast between a hyperpigmented skin lesion and skin surrounding the hyperpigmented skin lesion without directly affecting melanocytes or melanogenesis. The method includes the steps of applying a composition containing a material to be tested to the hyperpigmented skin lesion； and after an interval of time, observing whether the composition has effected at least one of inhibiting proliferation of keratinocytes, stimulating differentiation of keratinocytes, and improving compressive deformation of dermal papillae, in a basal layer of epidermis in the hyperpigmented lesion of skin.
