Clifford Riley King,Stephen G. DAmbrosio,David W. Bristol,Michael L. English
申请号：
US13953330
公开号：
US08846766B2
申请日:
2013.07.29
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Provided is a drug substance and a method of treating an ailment comprising administering an oral dose of a drug product comprising the drug substance wherein the drug substance comprises an organic acid addition salt of methadone. The organic acid addition salt is selected from the group consisting of pamoate and xinafoate wherein the drug substance is bioavailable under gastrointestinal administration but is not bioavailable under administration at a mucosal membrane other than gastrointestinal or release from a depot injectable product.
