Disclosed herein is microneedle devices, the medicine box including the microneedle device and the method using the microneedle device. Specifically, disclose a kind of equipment of biological barrier that subject is passed through for shipped material, comprising: which more micropins, respectively have bottom end and tip, at least one access is provided at the bottom end and the tip or between the bottom end and the tip The bottom end of substrate, the micropin is attached or is integrated on the substrate The storage being connect at least one with the bottom end of the microneedle array, wherein the storage includes pharmaceutical dosages delivery system, wherein the pharmaceutical dosages delivery system includes the medicament that be transported through the biological barrier, or for generating the device that be transported through the medicament of the biological barrier, and the device for detecting the physiological signal from receptor.
