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Compounds for enhancing p21 expression and methods of use thereof
专利权人:
Rajiv R. Ratan
发明人:
Rajiv R. Ratan,Brett C. Langley,Brian S. Ko
申请号:
US12663091
公开号:
US09029322B2
申请日:
2008.06.05
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present invention relates to a method for identifying a drug candidate for enhancing expression of p21cip1/waf1 in a human patient suffering from a medical condition that can be treated by enhancing expression of p21Cφ1/waf1. The method includes (a) providing a cell line comprising a nucleic acid sequence that comprises a p21cip1/waf1 promoter operationally ligated to a reporter domain (b) exposing the cell line to a compound and (c) identifying a compound that induces expression of the reporter domain. The compound that induces expression of the reporter domain is a drug candidate for treating a medical condition that can be treated by enhancing expression of p21cip1/waf1.
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