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EXTENDED RELEASE DOSAGE FORMS OF PREGABALIN
专利权人:
MAPI PHARMA LTD.;JIANGSU NHWA PHARMACEUTICAL CO., LTD.
发明人:
Yoram SELA,Shai RUBNOV
申请号:
US16318308
公开号:
US20190298675A1
申请日:
2017.07.16
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The present invention relates to extended-release pharmaceutical compositions comprising pregabalin or a salt thereof, which are adapted to release the pregabalin active ingredient according to a dual release profile. The formulations comprise two components, the first (fast ER) providing extended-release of the active ingredient in a short controlled manner lasting from about 4 to about 6 hours, and the second (slow ER or maintenance) providing extended release of the active ingredient over a period of 24 hours. The proportion of each component in the formulation may be adjusted to achieve the desired AUC and therapeutic effect following oral administration to a subject. The invention further relates to methods of using the pharmaceutical compositions for treating conditions and disorders which are responsive to pregabalin treatment, such as neuropathic pain associated with diabetic peripheral neuropathy (DPN), post herpetic neuralgia (PHN), epilepsy, seizures and fibromyalgia.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
相关发明人
shai rubnov
yoram sela
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