This invention provides for novel antiparasitic and pesticidal derivatives of avermectin and milbemycin compounds in which two avermectin or milbemycin members are linked together by a chemical linker. The resulting compounds may be used in veterinary compositions which are used in treating, controlling and preventing of endo- and ectoparasite infections in animals or for combating pests in plants or plant propagation material.本發明提供阿佛菌素(avermectin)及密倍脈心(avermectin)化合物之新穎抗寄生蟲性及殺蟲性衍生物,其中2個阿佛菌素或密倍脈心成員由化學連接基團連在一起。所得化合物可用於獸醫學組合物中,該等獸醫學組合物可用於治療、控制及預防動物之體內及體外寄生蟲感染或用於對抗植物或植物繁殖材料之害蟲。