VERWENDUNG VON MICROCYSTINEN ZUR HERSTELLUNG VON ARZNEIMITTELN ZUR PRÄVENTION ODER BEHANDLUNG VON ORGAN- UND GEWEBEFIBROSEERKRANKUNGEN

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专利权人:

Nanjing University

发明人:

WANG, Yaping,XU, Lizhi,WANG, Jie,ZHAO, Qingya

申请号：

EP17876506

公开号：

EP3549596A4

申请日:

2017.08.28

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

Use of microcystins having a monocyclic heptapeptide structure in preparation of drugs for preventing or treating organ and tissue fibrosis diseases. Preferably, the microcystins are microcystin-LR with amino acids at positions 2 and 4 of a monocyclic heptapeptide structure thereof being leucine and arginine respectively, or are microcystin-RR with amino acids at positions 2 and 4 thereof being both arginine. Also provided is a method for inhibiting myofibroblast differentiation and collagen synthesis. The method is implemented by inhibiting a TGF-β/Smad signaling pathway by using one or more microcystins.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/