Richard Elliott;Eileen M. Seward;Emanuela Gancia;Daniel P. Sutherlin;Timothy Heffron;Brian Safina;Robert Heald;BinQing Wei;Steven Staben;Bohdan Waskowycz
发明人:
Timothy Heffron,Brian Safina,Steven Staben,Daniel P. Sutherlin,BinQing Wei,Richard Elliott,Robert Heald,Eileen M. Seward,Emanuela Gancia,Bohdan Waskowycz
申请号：
US13424500
公开号：
US20120245144A1
申请日:
2012.03.20
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Benzoxazepin Formula I compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological disorders, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
