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HUMANIZED ANTIBODIES AGAINST IL-10 FOR TREATMENT OF SYSTEM RED Lupus erythematosus (SLT)
专利权人:
БИОТЕСТ АГ (DE)
发明人:
ОСТЕРРОТ Франк (DE),УЭРЕК Кристоф (DE),БРЮХЕР Кристоф (DE),РЕТТГЕН Петер (DE),ДЕЛКЕН Бенжамин (DE),ЭНГЛИНГ Андре (DE),ЦУБЕР Шанталь (DE),ЧЕЛОТ Никлас (DE),ВАРТЕНБЕРГ-ДЕМАНД Андреа (DE),ГУЧЕР Маркус (D
申请号:
RU2012127380/10
公开号:
RU2012127380A
申请日:
2010.11.30
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (IL-10), wherein said antibody or fragment thereof can be administered to a subject in the absence of an unacceptable increase in the level of pro-inflammatory cytokines. 2. The humanized or chimeric antibody or fragment thereof according to claim 1, wherein the antibody or fragment thereof can be administered to a subject in the absence of a rise in body temperature of more than 2 ° C. The humanized or chimeric antibody or fragment thereof according to claim 1 or 2, wherein the antibody or fragment thereof can be administered to a subject in the absence of an increase in pro-inflammatory cytokines of more than 500% of the upper limit of normal (ULN), where the pro-inflammatory cytokine is selected from TNF-α, INF-g, IL-1β. 4. The humanized or chimeric antibody or fragment thereof according to claim 3, wherein the antibody or fragment thereof can be administered to a subject in the absence of an increase in pro-inflammatory cytokines of more than 300% of the upper limit of norm (ULN). A humanized or chimeric antibody or fragment thereof according to claim 1 or 2, capable of stimulating an IL-1 receptor antagonist (IL-1ra) in an individual. The humanized or chimeric antibody or fragment thereof according to claim 1, wherein said antibody does not cause a more than 500% increase in the level of pro-inflammatory cytokines released from peripheral blood mononuclear cells (PBMCs) upon contact with said cell. The humanized or chimeric antibody or fragment thereof according to claim 1, 2 or 6, wherein the pro-inflammatory cytokine is at least one of TNF-α, INF-g and IL-1β. The humanized or chimeric antibody or fragment thereof according to claim 1, 2 or 6, wherein the antibody or fragment thereof is derived from an antibody1. Гуманизированное или химерное антитело или его фрагмент, способные связываться с интерлейкином-10 (IL-10), где указанное антитело или его фрагмент можно вводи
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