A system and method acquiring images of a region of interest (ROI) of a subject using a magnetic resonance imaging system. The system or method are capable of acquiring pathological data from tissue in the ROI believed to be pathological tissue and acquiring baseline data from tissue in the subject believed to not be pathological tissue. The system or method are also capable of determining correlation parameters from baseline data, generating corrected data using the baseline correlation parameters to correct the pathological data at least for intrinsic heterogeneity, and generating a report using the corrected data.
