MONOHYDRATE CRYSTALLINE FORM OF 3-(5-(4-(3-FLUOROPROPYL)-PIPERAZIN-1-YL)BENZIMIDAZOL-2-YL)-1-AZAAZULEN-2-ONE, PREPARATION METHOD, AND PHARMACEUTICAL COMPOSITION THEREOF
WEN, YEN FANG,温岩芳,溫岩芳,TSAI, YUAN JANG,蔡元彰,蔡元彰,CHEN, WAN RU,陈婉茹,陳婉茹,HU, TSAN LIN,胡璨麟,胡璨麟,TU, CHIA MU,杜佳穆,杜佳穆,LIU, CHIH PENG,刘志鹏,劉志鵬
申请号：
TW101147995
公开号：
TW201425309A
申请日:
2012.12.18
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
The present invention provides a monohydrate crystalline form of 3-(5-(4-(3-fluoropropyl)piperazin-1-yl)benzimidazol-2-yl)-1-azaazulen-2-one, possessing diffraction peaks of about 12.9°, 15.9°, 17.9°, 21.2°, 22.9°, 23.5°, and 24.5°. A method of preparing the above monohydrate crystalline form and a pharmaceutical composition containing the same are also provided.本發明提供一種3-(5-(4-(3-氟丙基)哌嗪-1-基)苯並咪唑-2-基)-1-氮雜薁-2-酮(式I)之單水合晶型,其X射線粉末繞射圖在約12.9、15.9、17.9、21.2、22.9、23.5、24.5度具有特徵峰。本發明亦提供前述單水合晶型之製備方法與藥學組成物。
