A surgical device for clipping tissue can include a replaceable cartridge comprising a stack of clips contained therein and a firing drive configured to reciprocatingly eject, or deploy, the clips from the cartridge. After the clips have been deployed from the cartridge, a blocking member can be positioned to impede or block the firing drive. In at least one embodiment, the cartridge can include a biasing member configured to bias the blocking member into a firing chamber defined in the cartridge and/or surgical device. The surgical device can also include a crimping drive configured to deform a clip after it has been ejected from the cartridge. The blocking member can also be configured to impede or block the crimping drive after all of the clips from the cartridge have been used.
