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(R)-N-methylnaltrexone, processes for its synthesis and its pharmaceutical use
- 专利权人:
- Progenics Pharmaceuticals; Inc.
- 发明人:
- Perez, Julio,Doshan, Harold D.
- 申请号:
- AU2012211459
- 公开号:
- AU2012211459A1
- 申请日:
- 2012.08.09
- 申请国别(地区):
- AU
- 年份:
- 2012
- 代理人:
- 摘要:
- #$%^&*AU2012211459A120120830.pdf#####C -NRPorbl\DCC\RXSUsI7415_ I DOC-9 /20I12 ABSTRACT This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use. Br Br Me OH OH N MeN 0 0 0 0 OH OH R-MNTX S-MNTX1/6 B? B? Me OH OH OH OH R-MNTX S-MNTX Fig. 1 S-MNTXi {R-MNTX 250200- o 0 150E 10050-19 2.5 5.0 7.5 10.0 12.5 15.0 MINUTES PEAK NO RET.TIME (MIN) AREA (COUNTS) SER CODE WIDTH 1/2 (SEC) RESULT 0 1 9.298 908375 BB 7.4 55.32 2 9.798 733746 BB 6.7 44.68 1642121 100.00 Fig. 2
- 来源网站:
- 中国工程科技知识中心
- 来源网址:
- http://www.ckcest.cn/home/