AKEDA PHARMACEUTICAL COMPANY LIMITED;TAKEDA PHARMACEUTICAL COMPANY LIMITED
发明人:
YASUMA, TSUNEO,TAKAKURA, NOBUYUKI
申请号：
ES09730930
公开号：
ES2476265T3
申请日:
2009.04.09
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound represented by formula (II): wherein ring A is a 6-membered ring optionally substituted by, in addition to -5 W1-R1 and -W2-R2, 1 to 3 halogen atoms； Ring B is a non-aromatic nitrogen-containing heterocycle of members optionally substituted by 1 to 3 substituents selected from (1) a C1-6 alkyl group optionally substituted by 1 to 3 substituents selected from (a) a hydroxy group, (b) a carbamoyl group optionally mono or substituted by substituent / s selected from (i) a C1-6 alkyl group optionally substituted by 1 to 3 substituents selected from a hydroxy group and a C1-6 alkoxy group, and (ii) a C3- cycloalkyl group C10, (c) a C1-6 alkoxy group, (d) a carboxy group, (e) a C1-6 alkoxycarbonyl group, (f) a non-aromatic heterocycle group, and (g) a non-heterocyclyl carbonyl group aromatic, and (2) a C1-6 alkoxycarbonyl group； W1 and W2 are both O； R1 is a C6-14 aryl group or a heterocyclic group, each of which is optionally substituted by 1 to 3 substituents selected from (1) a C1-6 alkylsulfonyl group, and (2) an optionally substituted C1-6 alkyl group by 1 to 3 C1-6 alkoxy groups； R2 is a C1-6 alkyl group optionally substituted by 1 to 3 substituents selected from (1) a C6-14 aryl group, (2) an aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from (a) a halogen atom , and (b) a C1-6 alkyl group, (3) a non-aromatic heterocycle group, (4) a hydroxy group, (5) a C1-6 alkoxy group, and (6) a di-tert-butylphenylsilyloxy group.Un compuesto representado por la fórmula (II): en la que anillo A es un anillo de 6 miembros opcionalmente sustituido por, además de -5 W1-R1 y -W2-R2, 1 a 3 átomos de halógeno； anillo B es un heterociclo no aromático que contiene nitrógeno de miembros opcionalmente sustituido por 1 a 3 sustituyentes seleccionados de (1) un grupo alquilo C1-6 opcionalmente sustituido por 1 a 3 sustituyentes seleccionados de (a) un grupo hidroxi, (b) un grupo carbamoilo opcionalmente mono o disustituido por sustituyente/s s
