A method of medical image processing for images of body structures, comprising: receiving anatomical data to reconstruct an anatomical image of a region of a body of a patient, said region comprises a portion of at least one internal body part which borders or is spaced apart from a target tissue receiving functional data from a functional imaging modality which images at least said portion of the region of the body of the patient processing said anatomical image to generate at least one image mask corresponding to the zone outside of the wall of said at least one internal body part correlating the at least one generated image mask with the functional data for guiding a reconstruction of a functional image depicting said target tissue and providing the reconstructed functional image.
