A method for searching for a substance suppressing a target odor through cross-adaptation is provided. A method for selecting a substance inducing cross-adaptation of a target odor includes: searching olfactory receptor polypeptides to identify an olfactory receptor polypeptide responding to a causative substance of the target odor； adding a test substance, which is different from the causative substance of the target odor, to the identified olfactory receptor polypeptide to measure response thereof； and selecting the test substance which activates the response of the olfactory receptor polypeptide as the substance inducing the cross-adaptation of the target odor.
