Lim, Se Young,Park, Sung Hee,Shin, Ryoung Ae,Choi, In Young,Kwon, Se Chang
申请号：
AU2013228152
公开号：
AU2013228152C1
申请日:
2013.03.08
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
The present invention relates to a pharmaceutical composition for the prevention and treatment of non-alcoholic fatty liver disease (NAFLD), including a conjugate prepared by covalently linking an insulinotropic peptide, a non-peptidyl polymer and an immunoglobulin Fc region. The composition of the present invention maintains the in-vivo activity of the peptide at a relatively high level, and remarkably increases the blood half-life, thereby preventing triglyceride accumulation which is a typical feature of non-alcoholic fatty liver disease. Ultimately, it can be desirably employed for the prevention and treatment of non-alcoholic fatty liver disease.
