KIM, BYONG MOON,LEE, SUNG HEE,KIM, TAE HYOUNG,KIM, YOON JI,KANG, SOO HYUNG,YOO, MOOHI,KWAK, HYUN HEE,LEE, GHUN IL,PARK, YONG MAN,SON, MI KYUNG,YANG, HI CHANG
申请号：
NZ58070008
公开号：
NZ580700A
申请日:
2008.04.18
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is a method for preparing a biodegradable polyester polymer microsphere comprising: adding a volatile organic solvent in which the polymer has solubility to a polyester polymer to yield a polymer solution (step 1) dispersing a glucose-regulating peptide in the polymer solution of step 1 to yield a drug dispersion and mixing an alcohol or a mixture of an alcohol and an organic acid with the drug dispersion to yield a drug-dispersed solution (step 2) and producing a microsphere from the drug-dispersed solution of step 2 (step 3). Also disclosed is a biodegradable polymeric microsphere for controlled release of a glucose-regulating peptide prepared using the method.
