Boris Rubinsky,Paul Mikus,Liel Rubinsky,Michael Klaus Stehling,Enric Günther
申请号：
US15570914
公开号：
US20180193082A1
申请日:
2015.05.13
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Example methods and apparatuses are disclosed for providing tissue ablation through electrolysis, electroporation, or a combination thereof. A way to deliver the combination through a pulse that has an element of gradual decay and can thereby reduce both muscle contraction and electric breakdown discharge at the electrodes is disclosed. The apparatus disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through a treatment site to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site.
