Disialyllacto-n-tetraose (dslnt) or variants, isomers, analogs and derivatives thereof to prevent or inhibit bowel disease

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专利权人:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人:

BODE LARS

申请号：

NZ61343212

公开号：

NZ613432A

申请日:

2012.02.03

申请国别(地区):

NZ

年份:

2016

代理人:

摘要：

Disclosed is an infant formula, baby food, or fortified breast milk, comprising a formulation comprising an isolated disialyllacto-N-tetraose (DSLNT) or isomer thereof and a probiotic, wherein the isolated DSLNT or isomer is free of non-DSLNT oligosaccharides and is present in the formulation at 300 &mu；M or greater, wherein DSLNT is biologically active &alpha；-Neu5Ac-(2&rarr；3)-&bgr；-Gal-(1&rarr；3)-[&alpha；-Neu5Ac-(2&rarr；6)]-&bgr；-GlcNAc-(1&rarr；3)-&bgr；-Gal-(1&rarr；4)-Glc； and wherein the isomer is any of &alpha；-Neu5Ac-(2&rarr；3)- &alpha；-Gal-(1&rarr；3)-[&alpha；-Neu5Ac-(2&rarr；6)]-&bgr；-GlcNAc-(1&rarr；3)-&bgr；-Gal-(1&rarr；4)-Glc, &alpha；-Neu5Ac-(2&rarr；3)-&bgr；-Gal-(1&rarr；3)-[&alpha；-Neu5Ac-(2&rarr；6)]- &alpha； -GlcNAc-(1&rarr；3)-&bgr；-Gal-(1&rarr；4)-Glc, &alpha；-Neu5Ac-(2&rarr；3)-&bgr；-Gal-(1&rarr；3)-[&alpha；-Neu5Ac-(2&rarr；6)]-&bgr；-GlcNAc-(1&rarr；3)- &alpha；-Gal-(1&rarr；4)-Glc, &bgr；-Neu5Ac-(2&rarr；3)-&bgr；-Gal-(1&rarr；3)-[&alpha；-Neu5Ac-(2&rarr；6)]-&bgr；-GlcNAc-(1&rarr；3)-&bgr；-Gal-(1&rarr；4)-Glc, or &alpha；-Neu5Ac-(2&rarr；3)-&bgr；-Gal-(1&rarr；3)-[ &bgr；-Neu5Ac-(2&rarr；6)]-&bgr；-GlcNAc-(1&rarr；3)-&bgr；-Gal-(1&rarr；4)-Glc. Also disclosed is a formulation in the form of a tablet, caplet or powder comprising &alpha；-Neu5Ac-(2&rarr；3)- &alpha；-Gal-(1&rarr；3)-[&alpha；-Neu5Ac-(2&rarr；6)]-&bgr；-GlcNAc-(1&rarr；3)-&bgr；-Gal-(1&rarr；4)-Glc, &alpha；-Neu5Ac-(2&rarr；3)-&bgr；-Gal-(1&rarr；3)-[&alpha；-Neu5Ac-(2&rarr；6)]- &alpha； -GlcNAc-(1&rarr；3)-&bgr；-Gal-(1&rarr；4)-Glc, &alpha；-Neu5Ac-(2&rarr；3)-&bgr；-Gal-(1&rarr；3)-[&alpha；-Neu5Ac-(2&rarr；6)]-&bgr；-GlcNAc-(1&rarr；3)- &alpha；-Gal-(1&rarr；4)-Glc, &bgr；-Neu5Ac-(2&rarr；3)-&bgr；-Gal-(1&rarr；3)-[&alpha；-Neu5Ac-(2&rarr；6)]-&bgr；-GlcNAc-(1&rarr；3)-&bgr；-Gal-(1&rarr；4)-Glc, or &alpha；-Neu5Ac-(2&rarr；3)-&bgr；-Gal-(1&rarr；3)-[ &bgr；-Neu5Ac-(2&rarr；6)]-&bgr；-GlcNAc-(1&rarr；3)-&bgr；-Gal-(1&rarr；4)-Glc.

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